منابع مشابه
Modification of cellular DNA by synthetic aziridinomitosenes.
Two synthetic aziridinomitosenes (AZMs), Me-AZM and H-AZM, structurally related to mitomycin C (MC) were evaluated for their anticancer activity against six cancer cell lines (HeLa, Jurkat, T47D, HepG2, HL-60, and HuT-78) and tested for their DNA-modifying abilities in Jurkat cells. Cytotoxicity assays showed that Me-AZM is up to 72-fold and 520-fold more potent than MC and H-AZM, respectively....
متن کاملSequence-specific modification of genomic DNA by small DNA fragments.
Small DNA fragments have been used to modify endogenous genomic DNA in both human and mouse cells. This strategy for sequence-specific modification or genomic editing, known as small-fragment homologous replacement (SFHR), has yet to be characterized in terms of its underlying mechanisms. Genotypic and phenotypic analyses following SFHR have shown specific modification of disease-causing geneti...
متن کاملModification of Deposited, Size-Selected MoS2 Nanoclusters by Sulphur Addition: An Aberration-Corrected STEM Study
Molybdenum disulphide (MoS2) is an earth-abundant material which has several industrial applications and is considered a candidate for platinum replacement in electrochemistry. Size-selected MoS2 nanoclusters were synthesised in the gas phase using a magnetron sputtering, gas condensation cluster beam source with a lateral time-of-flight mass selector. Most of the deposited MoS2 nanoclusters, a...
متن کاملModification of Oxygen and Sulphur Inclusions in Steel by Calcium Treatment
The non-metallic inclusions are inevitable consequence of metal elaboration processes and are foreign phases always present in solid and liquid metal. The inclusions have a different shape and a size from several to several hundred micrometers (in diameter). They are randomly distributed in the matrix of the base metal and form a dispersion phase in liquid and in solid metallic phase. The non–m...
متن کاملdecolorization of basic textile dyes using a novel adsorbent modification method: ultrasonic-acid modification
in this study, removal of methylene blue (mb) and maxilon blue sl 200% (mb sl) dyes from aqueous solutions by using raw clay (rc) of nevsehir (turkey) vicinity and ultrasonic-acid modified clay (mc) was investigated. adsorption was carried out with 500 mg/l mb and 50 mg/l for mb sl in terms of different adsorbent dosages, contact time, solution ph, temperature and stirring speed. the fitting of...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2005
ISSN: 0950-382X
DOI: 10.1111/j.1365-2958.2005.04764.x